|Title:||Cembranoid-related metabolites and biological activities from the soft coral sinularia flexibilis||Authors:||Wu, Chia Hua
Chao, Chih Hua
Huang, Tzu Zin
Huang, Chiung Yao
Hwang, Tsong Long
Sheu, Jyh Horng
|Keywords:||Cembranoid-related compounds | Flexibilisin | Flexibilisolide | Secoflexibilisolide | Sinularia flexibilis||Issue Date:||9-Aug-2018||Publisher:||MDPI||Journal Volume:||16||Journal Issue:||8||Source:||Marine Drugs||Abstract:||
© 2018 by the authors. Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
|Appears in Collections:||海洋研究所|
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