https://scholars.lib.ntu.edu.tw/handle/123456789/411230| Title: | Cembranoid-related metabolites and biological activities from the soft coral sinularia flexibilis | Authors: | Wu, Chia Hua Chao, Chih Hua Huang, Tzu Zin Huang, Chiung Yao Hwang, Tsong Long CHANG-FENG DAI Sheu, Jyh Horng |
Keywords: | Cembranoid-related compounds | Flexibilisin | Flexibilisolide | Secoflexibilisolide | Sinularia flexibilis | Issue Date: | 9-Aug-2018 | Publisher: | MDPI | Journal Volume: | 16 | Journal Issue: | 8 | Source: | Marine Drugs | Abstract: | © 2018 by the authors. Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/411230 | ISSN: | 1660-3397 | DOI: | 10.3390/md16080278 |
| Appears in Collections: | 海洋研究所 |
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