|Title:||Briarenones A-C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum||Authors:||Cheng, Yang
Ahmed, Atallah F.
Orfali, Raha S.
Sheu, Jyh Horng
|Keywords:||Briarellin | Briarenones | Briareum violaceum | Gorgonian||Issue Date:||17-Feb-2019||Publisher:||MDPI||Journal Volume:||17||Journal Issue:||2||Source:||Marine Drugs||Abstract:||
© 2019 by the authors. Three new eunicellin-derived diterpenoids of briarellin type, briarenones A-C (1-3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively.
|Appears in Collections:||海洋研究所|
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