Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis
Journal
International journal of obesity (2005)
Journal Volume
43
Journal Issue
1
Pages
73-81
Date Issued
2019
Author(s)
Abstract
Obesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the causal direction of the relationship between adiposity and asthma using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.
SDGs
Other Subjects
allele; allergic asthma; Article; asthma; body fat; body mass; child; childhood obesity; fat free mass; female; gene frequency; genetic variability; genome-wide association study; genotype; human; major clinical study; male; Mendelian randomization analysis; pleiotropy; priority journal; school child; single nucleotide polymorphism; skinfold; waist hip ratio; asthma; childhood obesity; complication; genetics; Mendelian randomization analysis; obesity; odds ratio; Taiwan; Adiposity; Alleles; Asthma; Body Mass Index; Child; Female; Genome-Wide Association Study; Humans; Male; Mendelian Randomization Analysis; Odds Ratio; Pediatric Obesity; Polymorphism, Single Nucleotide; Taiwan
Publisher
NATURE PUBLISHING GROUP
Type
journal article