No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population
Journal
Journal of the Formosan Medical Association = Taiwan yi zhi
Journal Volume
117
Journal Issue
7
Pages
646-649
Date Issued
2018-07
Author(s)
Abstract
Cytochrome P450 2E1 (CYP2E1) gene is one of the candidate genes for alcohol dependence (AD). Four single nucleotide polymorphisms (SNPs) of CYP2E1 gene (CYP2E1*1D, *5B, *6 and *1B) have been associated with AD previously in other ethnic populations. To date, only CYP2E1*5B and *6 SNPs have been investigated in relation to AD in our population. The objective of the study was to examine the genetic associations of CYP2E1 covering the four above-noted SNPs conjointly with AD in Han Taiwanese population based on single SNP analysis and haplotype-based approach. We enrolled a total of 340 patients fulfilling DSM-IV-TR diagnostic criteria of AD and 319 healthy controls and genotyped them for the above four SNPs of CYP2E1 gene. By comparing the differences of genotype, allele, and pertinent haplotype frequencies, we did not support a genetic association between CYP2E1 and AD in Han Taiwanese either by single allele tests or haplotype-based analyses.
Subjects
Alcohol dependence; CYP2E1 gene; Haplotype; Single nucleotide polymorphisms; Taiwan
SDGs
Other Subjects
cytochrome P450 2E1; cytochrome P450 2E1; adult; aged; alcoholism; allele; Article; controlled study; DSM-IV-TR; female; gene frequency; genetic association; genotype; haplotype; human; major clinical study; male; single nucleotide polymorphism; Taiwanese; alcoholism; Asian continental ancestry group; case control study; genetics; middle aged; statistical model; Taiwan; Adult; Alcoholism; Alleles; Asian Continental Ancestry Group; Case-Control Studies; Cytochrome P-450 CYP2E1; Female; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Polymorphism, Single Nucleotide; Taiwan
Publisher
ELSEVIER TAIWAN
Type
journal article