BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation
Journal
Journal of dermatological science
Journal Volume
92
Journal Issue
2
Pages
151
Date Issued
2018-11
Author(s)
Abstract
B lymphocyte-induced maturation protein-1 (BLIMP1) is a transcriptional repressor, and plays a crucial role in the regulation of development and functions of various immune cells. Currently, there is limited understanding about the regulation of BLIMP1 expression in keratinocytes and crosstalk between EGFR and BLIMP1 in skin homeostasis.
Subjects
BLIMP1; Differentiation; EGFR; Inflammation; Keratinocyte
Publisher
ELSEVIER IRELAND LTD
Type
journal article