|Title:||New and bioactive sesquiterpenes from Schisandra sphenanthera||Authors:||Mendbayar K.
|Keywords:||(-)-£^-Cuparenol;Immuno-modulating activity;Schisandra sphenanthera;Schisansphenins A and B||Issue Date:||2011||Journal Volume:||94||Journal Issue:||12||Start page/Pages:||2295-2302||Source:||Helvetica Chimica Acta||Abstract:||
Three new sesquiterpenes, schisansphenins A (1) and B (2) and (-)-£^-cuparenol (3), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D-NMR experiments ( 1H, 1H-COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B (2) is proposed. Compounds 2 and 3 significantly reduced activation of NF-AT and NF-£eB in the luciferase-reporter assay. Copyright ? 2011 Verlag Helvetica Chimica Acta AG, Z?rich, Switzerland.
|Appears in Collections:||食品科技研究所|
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