The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes
Journal
Scandinavian journal of immunology
Journal Volume
39
Journal Issue
5
Date Issued
1994-05
Author(s)
Abstract
(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases.
SDGs
Other Subjects
autoantibody; dna antibody; immunoglobulin g; interleukin 2; animal experiment; article; autoimmunity; b lymphocyte; enzyme linked immunosorbent assay; female; immunization; mouse; nonhuman; photoreactivity; spleen cell; systemic lupus erythematosus; t lymphocyte; Animal; Antibodies, Antinuclear; Autoimmune Diseases; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Photopheresis; Spleen; Support, Non-U.S. Gov't
Type
journal article