|Title:||The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes||Authors:||LI-FANG WANG||Issue Date:||May-1994||Journal Volume:||39||Journal Issue:||5||Source:||Scandinavian journal of immunology||Abstract:||
(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases.
|Appears in Collections:||醫學系|
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