The protective role of carotenoids and polyphenols in patients with head and neck cancer
Journal
Journal of the Chinese Medical Association
Journal Volume
78
Journal Issue
2
Pages
89-95
Date Issued
2015
Author(s)
Abstract
Head and neck cancer is a critical global health problem and approximately 650,000 patients per year are diagnosed with this type of cancer. In addition, head and neck cancer exhibits a high recurrence rate, readily causing second primary cancers in other locations, often yielding a poor prognosis. Current medical and surgical treatment options result in considerable impairment of speaking and swallowing functions, with side effects such as nausea, vomiting, bone marrow suppression, and renal damage, thereby impairing patients' quality of life. Thus, developing a prevention and therapeutic intervention strategy for head and neck cancer is vital. Phytochemicals have been shown to have a unique ability to protect cells from damage and modulation of cell repair. The chemopreventive activities of phytochemicals have also been demonstrated to be associated with their antioxidant properties and the induction and stimulation of intercellular communication via gap junctions, which play a role in the regulation of cancer cell cycle, differentiation, apoptosis, and stagnate cancer cell growth. Phytochemicals can also regulate cancer cell signaling pathways, reduce the invasion and metastasis of cancer cells, and protect normal cells during treatment, thus reducing the damage caused by chemotherapy and radiotherapy. The most studied of the chemopreventive effects of phytochemicals are the carotenoids and phenolics. In this review, we investigated the multiple mechanisms of carotenoids and polyphenols (PPs) for use in preventing head and neck cancer, reducing the side effects of chemotherapy and radiotherapy, improving patient survival rates, and reducing the occurrence rate of second primary cancers. ? 2014.
Subjects
Chemotherapy
Head and neck cancer
Phytochemicals
Radiotherapy
Supplementary therapeutic agents
SDGs
Other Subjects
carotenoid; polyphenol; proanthocyanidin; antineoplastic agent; carotenoid; plant medicinal product; polyphenol; apoptosis; betel nut; cancer cell; cancer growth; cancer prevention; cancer survival; cell communication; cell differentiation; cell regeneration; chemoprophylaxis; dietary intake; drug mechanism; head and neck cancer; human; nonhuman; phytonutrient; Review; tea; Head and Neck Neoplasms; multimodality cancer therapy; Antineoplastic Agents; Carotenoids; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Phytochemicals; Polyphenols
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
1-s2.0-S1726490114002317.pdf
Size
376.13 KB
Format
Adobe PDF
Checksum
(MD5):300375f9378f15648575a7dea460b168