https://scholars.lib.ntu.edu.tw/handle/123456789/413588
標題: | Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B 1 -induced oxidative stress and DNA damage in primary cultured rat hepatocytes | 作者: | Lin W.C. Liao Y.C. Liau M.C. Lii C.K. Sheen L.Y. |
關鍵字: | A urinary preparation;Aflatoxin B 1;CDA-II;DNA damage;Lipid peroxidation;Primary rat hepatocytes | 公開日期: | 2006 | 卷: | 44 | 期: | 4 | 起(迄)頁: | 546-551 | 來源出版物: | Food and Chemical Toxicology | 摘要: | The effects of CDA-II (cell differentiation agent II; a urinary preparation) on both aflatoxin B 1 (AFB 1 )-induced cell injury and DNA damage were investigated using cultured rat hepatocytes. CDA-II was able to suppress both the lipid peroxidation and lactate dehydrogenase leakage induced by AFB 1 . Glutathione (GSH) depletion by AFB 1 was replenished by CDA-II treatment. Under these experimental conditions, CDA-II enhanced the activity of GSH peroxidase, but not GSH S-transferase. By evaluation of unscheduled DNA synthesis, CDA-II reduced AFB 1 -induced DNA damage in hepatocyte cultures. These findings suggest that CDA-II can inhibit cytotoxicity of AFB 1 through enhancing the activity of GSH peroxidase and preventing GSH depletion. ? 2005 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/413588 | ISSN: | 2786915 | DOI: | 10.1016/j.fct.2005.08.029 |
顯示於: | 食品科技研究所 |
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