https://scholars.lib.ntu.edu.tw/handle/123456789/413623
標題: | 3¡¬-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/STAT3 Signaling in Mice | 作者: | Lai C.-S. Yang G. Li S. Lee P.-S. Wang B.N. Chung M.-C. Nagabhushanam K. Ho C.-T. MIN-HSIUNG PAN |
關鍵字: | 3¡¬-hydroxypterostilbene;azoxymethane;colitis;dextran sodium sulfate;inflammation | 公開日期: | 2017 | 卷: | 65 | 期: | 44 | 起(迄)頁: | 9655-9664 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | 3¡¬-Hydroxypterostilbene (trans-3,5-dimethoxy-3¡¬,4¡¬-hydroxystilbene) presents in Sphaerophysa salsula, Pterocarpus marsupium, and honey bee propolis and has been reported to exhibit several biological activities. Herein, we aimed to explore the chemopreventive effects of dietary 3¡¬-hydroxypterostilbene and underlying molecular mechanisms on colitis-associated cancer using the azoxymethane (AOM)/dextran sodium sulfate (DSS) model. 3¡¬-Hydroxypterostilbene administration effectively ameliorated the colon shortening and number of tumors in AOM/DSS-treated mice (3.2 ¡Ó 1.2 of the high-dose treatment versus 13.8 ¡Ó 5.3 of the AOM/DSS group, p < 0.05). Molecular analysis exhibited the anti-inflammatory activity of 3¡¬-hydroxypterostilbene by a significant decrease in the levels of inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-6 (IL-6) (p < 0.05). Moreover, dietary 3¡¬-hydroxypterostilbene also significantly diminished IL-6/signal transducer and activator of transcription signaling and restored colonic suppressor of cytokine signaling 3 levels in the colonic tissue of mice (p < 0.05). Collectively, these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary 3¡¬-hydroxypterostilbene against colitis-associated colonic tumorigenesis. ? 2017 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/413623 | ISSN: | 00218561 | DOI: | 10.1021/acs.jafc.7b03712 | SDG/關鍵字: | Immunology; Mammals; Nitric oxide; Sodium; Sodium sulfate; Sulfur compounds; Anti-inflammatory activity; azoxymethane; Chemopreventive effects; colitis; High-dose treatment; Inducible nitric oxide synthase; inflammation; Suppressor of cytokine signaling 3; Diseases; 3'-hydroxypterostilbene; antineoplastic agent; cyclooxygenase 2; interleukin 6; STAT3 protein; stilbene derivative; animal; carcinogenesis; colitis; colon tumor; complication; disease model; drug effects; genetics; human; Institute for Cancer Research mouse; male; metabolism; mouse; signal transduction; Animals; Anticarcinogenic Agents; Carcinogenesis; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Humans; Interleukin-6; Male; Mice; Mice, Inbred ICR; Signal Transduction; STAT3 Transcription Factor; Stilbenes |
顯示於: | 食品科技研究所 |
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