https://scholars.lib.ntu.edu.tw/handle/123456789/414082
標題: | Self-nanoemulsifying system (SNES) enhanced oral bioavailability of boswellic acids | 作者: | Ting Y. Jiang Y. Zhao S. Li C.C. Nibber T. Huang Q. |
關鍵字: | Bioavailability;Boswellic acid;Lipolysis;Pharmacokinetics;Self-emulsification | 公開日期: | 2018 | 卷: | 40 | 起(迄)頁: | 520-526 | 來源出版物: | Journal of Functional Foods | 摘要: | Boswellia serrate gum resin extract is a potent anti-inflammatory agent that is widely used in ancient and modern medicinal systems. However, the efficacy of this bioactive ingredient is questionable due to its poor oral bioavailability. In this work, self-nanoemulsifying system (SNES) was used to enhance the systemic concentration of boswellic acids. The systemic concentrations of 11-keto-£]-boswellic acid (KBA) and acetyl-11-keto-£]-boswellic acid (AKBA), the most bioactive components of boswellic acids, were used as indicators to evaluate the efficiency of self-emulsifying system. In the study of lipolysis, the aqueous solubility and bioaccessibility of KBA and AKBA were increased by 2.7 and 2.3 folds, respectively. From the in vivo pharmacokinetic study, SNES triggered a significant increase in the oral bioavailability of KBA and AKBA by 2.2 and 2.0 times higher than the bulk oil suspension, respectively. Therefore, SNES with superior storage stability is an effective oral formulation to enhance bioavailability of boswellic acids. ? 2017 |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/414082 | ISSN: | 17564646 | DOI: | 10.1016/j.jff.2017.11.043 |
顯示於: | 食品科技研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。