https://scholars.lib.ntu.edu.tw/handle/123456789/414354
標題: | Models for the mechanism for activating copper-zinc superoxide dismutase in the absence of the CCS cu chaperone in Arabidopsis | 作者: | Huang, Chien Hsun Kuo, Wen Yu TSUNG-LUO JINN |
關鍵字: | Arabidopsis | CCS | CuZnSOD | GSH | SOD activation | 公開日期: | 1-一月-2012 | 卷: | 7 | 期: | 3 | 來源出版物: | Plant Signaling and Behavior | 摘要: | Copper-zinc superoxide dismutase (CuZnSOD; CSD) is an important antioxidant enzyme for oxidative stress protection. To date, two activation pathways have been identified in many species. One requiring the CCS, Cu chaperone for SOD, to insert Cu and activate CSD (referred to as CCSdependent pathway), and the other works independently of CCS (referred to as CCS-independent pathway). In our previous study, we suggest an unidentified factor will work with glutathione (GSH) for CSD activation in the absence of the CCS. Here, two models of the CCSindependent mechanism are proposed. The role of the unidentified factor may work as a scaffold protein, which provides a platform for the CSD protein and Cu-GSH to interact, or as a Cu carrier, which itself can bind Cu and interact with CSD proteins. We also suggest that the CSD protein conformation at C-terminal is important in providing a docking site for unidentified factor to access. © 2012 Landes Bioscience. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/414354 | ISSN: | 15592316 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85045352144 10.4161/psb.19192 |
顯示於: | 植物科學研究所 |
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