|Title:||Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine||Authors:||Chi-Chien Lin
|Keywords:||citrus peels; imiquimod; inflammation; plasmacytoid dendritic cell; psoriasis||Issue Date:||2018||Publisher:||Wiley||Journal Volume:||98||Journal Issue:||14||Start page/Pages:||5509||Source:||Journal of the Science of Food and Agriculture||Abstract:||
© 2018 Society of Chemical Industry BACKGROUND: Gold lotion (GL), a natural mixed product made from the peels of six citrus fruits, has recently been identified as possessing anti-oxidative, anti-inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV-induced damage, but its activity against psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is not known. We therefore evaluated the effect of GL on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. RESULTS: GL treatment significantly attenuated IMQ-induced psoriasis-like symptoms in mice. The inflammatory cytokines upregulated by IMQ in skin lesions were also inhibited by feeding GL. In addition, GL treatment reduced the infiltration of CD4 + T cells/neutrophils in skin lesions and the percentage of IL-17-/IL-22-producing T cells in lymph nodes. Furthermore, GL impaired IMQ-induced type I interferon production by plasmacytoid dendritic cells (pDCs) in vitro. CONCLUSION: Our results indicate GL can act to suppress the initiation of psoriasis and strongly suggest that GL may have potential to be applied to the treatment of psoriasis. © 2018 Society of Chemical Industry.
|Appears in Collections:||免疫學研究所|
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