Patient derived induced pluripotent stem cells for models of cancer and cancer stem cell research
Journal
Journal of the Formosan Medical Association
Journal Volume
117
Journal Issue
12
Pages
1046 1057
Date Issued
2018
Author(s)
H. M. Chao
Abstract
Induced pluripotent stem cells (iPSCs) are embryonic stem cell-like cells reprogrammed from somatic cells by four transcription factors, OCT4, SOX2, KLF4 and c-MYC. iPSCs derived from cancer cells (cancer-iPSCs) could be a novel strategy for studying cancer. During cancer cell reprogramming, the epigenetic status of the cancer cell may be altered, such that it acquires stemness and pluripotency. The cellular behavior of the reprogrammed cells exhibits dynamic changes during the different stages of reprogramming. The cells may acquire the properties of cancer stem cells (CSCs) during the process of reprogramming, and lose their carcinogenic properties during reprogramming into a cancer-iPSCs. Differentiation of cancer-iPSCs by teratoma formation or organoid culturing could mimic the process of tumorigenesis. Some of the molecular mechanisms associated with cancer progression could be elucidated using the cancer-iPSC model. Furthermore, cancer-iPSCs could be expanded in culture system or bioreactors, and serve as cell sources for research, and as personal disease models for therapy and drug screening. This article introduces cancer studies that used the cell reprogramming strategy. ? 2018
Subjects
Cancer stem cell; Cell reprogramming; Induced pluripotent stem cells (iPSCs); Tumorigenesis
SDGs
Other Subjects
transcription factor; transcription factor; breast cancer; cancer model; cancer patient; cancer research; cancer stem cell; carcinogenesis; cell differentiation; cell function; colon cancer; drug screening; embryonic stem cell; gene mutation; human; induced pluripotent stem cell; leukemia; liver cancer; lung cancer; nuclear reprogramming; oncogene c myc; osteosarcoma; pancreas cancer; Review; animal; cancer transplantation; carcinogenesis; genetics; neoplasm; oncology; stem cell research; Animals; Carcinogenesis; Cell Differentiation; Cellular Reprogramming; Humans; Induced Pluripotent Stem Cells; Medical Oncology; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Stem Cell Research; Transcription Factors
Type
journal article