Concurrent leukoencephalomyelitis and polyneuritis in a Maltese terrier: resembling combined central and peripheral demyelination in humans.
Journal
The Journal of veterinary medical science
Date Issued
2019
Author(s)
Li, Wen-Ta
Wu, Chih-Ching
Tu, Yang-Chang
Huang, Wei-Hsiang
Chang, Hui-Wei
Pang, Victor Fei
Jeng, Chian-Ren
Liu, Chen-Hsuan
WEI-HSIANG HUANG
Wu, Chih Ching
Chang, Hui Wei
CHEN-HSUAN LIU
Li, Wen Ta
Tu, Yang Chang
Abstract
A one-year-old male Maltese terrier presented with mild ataxia and disorientation for 4 months. Over time, clinical signs progressed from paraparesis to non-ambulatory tetraparesis, voice change and dysphagia. Histological examination revealed concurrent leukoencephalomyelitis and polyneuritis. Infectious etiologies, including dengue, Japanese encephalitis, Zika, canine distemper, pseudorabies, rabies, toxoplasmosis, neosporosis, leishmaniasis, and encephalitozoonosis, were ruled out by PCR and/or immunohistochemical (IHC) staining. IHC tested on neurological tissues highlighted a heterogeneous population of infiltrating T and B lymphocytes admixed macrophages. Therefore, this case was diagnosed with current leukoencephalomyelitis and polyneuritis, resembling combined central and peripheral demyelination (CCPD), an autoimmune inflammatory demyelinating disease affecting both the CNS and PNS in humans.
SDGs
Other Subjects
animal; case report; demyelinating disease; dog; dog disease; encephalomyelitis; immunohistochemistry; male; neuritis; pathology; veterinary medicine; Animals; Demyelinating Diseases; Dog Diseases; Dogs; Encephalomyelitis; Immunohistochemistry; Male; Neuritis
Type
journal article