https://scholars.lib.ntu.edu.tw/handle/123456789/416713
標題: | Galectin-1-Mediated tumor invasion and metastasis, Up-Regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons | 作者: | Wu, M.-H. Hong, T.-M. Cheng, H.-W. SZU-HUA PAN Liang, Y.-R. Hong, H.-C. Chiang, W.-F. Wong, T.-Y. Shieh, D.-B. Shiau, A.-L. Jin, Y.-T. Chen, Y.-L. |
公開日期: | 2009 | 出版社: | AMER ASSOC CANCER RESEARCH | 卷: | 7 | 期: | 3 | 起(迄)頁: | 311 | 來源出版物: | Molecular Cancer Research | 摘要: | Galectin-1 (Gal-1) is a β-galactose-binding lectin; its expression level has been reported to correlate with tumor progression, Gal-1 is highly expressed in the invasive front of primary tumors and in the cancer cells of metastatic lesions in the lymph nodes of patients with oral squamous cell carcinoma. However, the molecular mechanism of Gal-1 in tumor metastasis is not completely clear. We found that increased Gal-1 expression is closely associated with its high levels of invasion in lung adenocarcinoma and oral squamous cell carcinoma cell lines. Knocking down Gal-1 with small interfering RNA in highly invasive cancer ceils reduced their invasion levels. Moreover, the invasion ability of poorly invasive cancer cells was significantly increased after Gal-1 overexpression of Gal-1. Mechanism studies revealed that Gal-1 promoted tumor invasion mainly by up-regulating matrix metalloproteinase (MMP)-9 and MMP-2 and by reorganizing actin cytoskeleton. Gal-1 enhanced the activation of Cdc42, a small GTPase and member of the Rho family, thus increasing the number and length of filopodia on tumor cells. Furthermore, Gal-1 -overexpressing cells had higher metastatic abilities in tail vein metastasis assays in vivo. We conclude that Gal-1 is involved in tumor invasion and metastasis by increasing MMP expression and reorganizing cytoskeletons in oral cancers and lung adenocarcinoma. © 2009 American Association for Cancer Research. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-62549096778&partnerID=MN8TOARS https://scholars.lib.ntu.edu.tw/handle/123456789/416713 |
ISSN: | 1541-7786 1557-3125 |
DOI: | 10.1158/1541-7786.MCR-08-0297 60947647 |
顯示於: | 基因體暨蛋白體醫學研究所 |
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