https://scholars.lib.ntu.edu.tw/handle/123456789/416731
標題: | The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking | 作者: | Wang, I-Hao Chen, Yi-Jie Hsu, J. W. Fang-Jen Scott Lee |
關鍵字: | Arl1; Arl3; Atg9; COG complex; Cog8; Cvt pathway; selective autophagy; trans-Golgi trafficking | 公開日期: | 2017 | 出版社: | WILEY | 卷: | 18 | 期: | 9 | 起(迄)頁: | 580 | 來源出版物: | Traffic (Copenhagen, Denmark) | 摘要: | The Arl3-Arl1 GTPase cascade plays important roles in vesicle trafficking at the late Golgi and endosomes. Subunits of the conserved oligomeric Golgi (COG) complex, a tethering factor, are important for endosome-to-Golgi transport and contribute to the efficient functioning of the cytoplasm-to-vacuole targeting (Cvt) pathway, a well-known selective autophagy pathway. According to our findings, the Arl3-Arl1 GTPase cascade co-operates with Cog8 to regulate the Cvt pathway via Atg9 trafficking. arl3cog8Δ and arl1cog8Δ exhibit profound defects in aminopeptidase I maturation in rich medium. In addition, the Arl3-Arl1 cascade acts on the Cvt pathway via dynamic nucleotide binding. Furthermore, Atg9 accumulates at the late Golgi in arl3cog8Δ and arl1cog8Δ cells under normal growth conditions but not under starvation conditions. Thus, our results offer insight into the requirement for multiple components in the Golgi-endosome system to determine Atg9 trafficking at the Golgi, thereby regulating selective autophagy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026306172&doi=10.1111%2ftra.12498&partnerID=40&md5=a309096e91aa7aabad7c444a44f6bdff https://scholars.lib.ntu.edu.tw/handle/123456789/416731 |
ISSN: | 1398-9219 | DOI: | 10.1111/tra.12498 |
顯示於: | 分子醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。