https://scholars.lib.ntu.edu.tw/handle/123456789/416733
標題: | ARF GTPases and their GEFs and GAPs: concepts and challenges | 作者: | Sztul, Elizabeth Chen, Pei-Wen Casanova, James E Cherfils, Jacqueline Dacks, Joel B Lambright, David G Fang-Jen Scott Lee Randazzo, Paul A Santy, Lorraine C Sch?rmann, Annette Wilhelmi, Ilka Yohe, Marielle E Kahn, Richard A |
公開日期: | 2019 | 出版社: | AMER SOC CELL BIOLOGY | 卷: | 30 | 期: | 11 | 起(迄)頁: | 1249 | 來源出版物: | Molecular biology of the cell | 摘要: | Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional information, as one can include analyses of their coevolution, acquisition or loss of functionalities, structural pliability, and the emergence of shared or variations in molecular mechanisms. An even richer understanding of cell biology can be achieved through evaluating functionally linked protein families. In this review, we summarize current knowledge of three protein families: the ARF GTPases, the guanine nucleotide exchange factors (ARF GEFs) that activate them, and the GTPase-activating proteins (ARF GAPs) that have the ability to both propagate and terminate signaling. However, despite decades of scrutiny, our understanding of how these essential proteins function in cells remains fragmentary. We believe that the inherent complexity of ARF signaling and its regulation by GEFs and GAPs will require the concerted effort of many laboratories working together, ideally within a consortium to optimally pool information and resources. The collaborative study of these three functionally connected families (≥70 mammalian genes) will yield transformative insights into regulation of cell signaling. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066878630&doi=10.1091%2fmbc.E18-12-0820&partnerID=40&md5=f920de33d03e15a2d97083f120f4c530 https://scholars.lib.ntu.edu.tw/handle/123456789/416733 |
ISSN: | 1059-1524 | DOI: | 10.1091/mbc.E18-12-0820 |
顯示於: | 分子醫學研究所 |
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