https://scholars.lib.ntu.edu.tw/handle/123456789/416740
標題: | Adhesive L1CAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite Fasciculation in C. elegans | 作者: | CHUN-HAO CHEN Hsu, Hao-Wei Chang, Yun-Hsuan CHUN-LIANG PAN |
關鍵字: | C. elegans; F-actin; Robo; axon; cell adhesion molecule; cytoskeleton; dendrite; fasciculation; growth cone; somatosensation | 公開日期: | 2019 | 出版社: | Cell Press | 卷: | 48 | 期: | 2 | 起(迄)頁: | 215 - 228.e5 | 來源出版物: | Developmental cell | 摘要: | Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation is mediated by a previously uncharacterized adhesive signaling by the ALA membrane signal SAX-7/L1CAM and the PVD receptor SAX-3/Robo but independent of Slit. L1CAM physically interacts with Robo and instructs dendrite adhesion in a Robo-dependent manner. Fasciculation mediated by L1CAM-Robo signaling aligns F-actin dynamics in the dendrite growth cone and facilitates dynamic growth cone behaviors for efficient dendrite guidance. Disruption of PVD dendrite fasciculation impairs nociceptive mechanosensation and rhythmicity in body curvature, suggesting that dendrite fasciculation governs the functions of mechanosensory circuits. Our work elucidates the molecular mechanisms by which adhesive axon-dendrite signaling shapes the construction and function of sensory neuronal circuits. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060292588&doi=10.1016%2fj.devcel.2018.10.028&partnerID=40&md5=069c03b06d2832273837b03161b6f08b https://scholars.lib.ntu.edu.tw/handle/123456789/416740 |
ISSN: | 15345807 | DOI: | 10.1016/j.devcel.2018.10.028 |
顯示於: | 分子醫學研究所 |
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