https://scholars.lib.ntu.edu.tw/handle/123456789/416761
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chuang, Mei-Chun | en_US |
dc.contributor.author | Lin, Shan-Shan | en_US |
dc.contributor.author | Ohniwa, Ryosuke L. | en_US |
dc.contributor.author | Lee, Gang-Hui | en_US |
dc.contributor.author | Su, You-An | en_US |
dc.contributor.author | Chang, Yu-Chen | en_US |
dc.contributor.author | Tang, Ming-Jer | en_US |
dc.contributor.author | SHIH-SHUN LIN | en_US |
dc.creator | Chuang, Mei-Chun;Lin, Shan-Shan;Ohniwa, Ryosuke L;Lee, Gang-Hui;Su, You-An;Chang, Yu-Chen;Tang, Ming-Jer;Ya-Wen Liu | - |
dc.date.accessioned | 2019-08-28T11:47:10Z | - |
dc.date.available | 2019-08-28T11:47:10Z | - |
dc.date.issued | 2019-05-06 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065519622&doi=10.1083%2fjcb.201809161&partnerID=40&md5=504859647f460c31dd14d034bf99765d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/416761 | - |
dc.description.abstract | Skeletal muscle development requires the cell-cell fusion of differentiated myoblasts to form muscle fibers. The actin cytoskeleton is known to be the main driving force for myoblast fusion; however, how actin is organized to direct intercellular fusion remains unclear. Here we show that an actin- and dynamin-2-enriched protrusive structure, the invadosome, is required for the fusion process of myogenesis. Upon differentiation, myoblasts acquire the ability to form invadosomes through isoform switching of a critical invadosome scaffold protein, Tks5. Tks5 directly interacts with and recruits dynamin-2 to the invadosome and regulates its assembly around actin filaments to strengthen the stiffness of dynamin-actin bundles and invadosomes. These findings provide a mechanistic framework for the acquisition of myogenic fusion machinery during myogenesis and reveal a novel structural function for Tks5 and dynamin-2 in organizing actin filaments in the invadosome to drive membrane fusion. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ROCKEFELLER UNIV PRESS | en_US |
dc.relation.ispartof | The Journal of cell biology | en_US |
dc.title | Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1083/jcb.201809161 | - |
dc.identifier.pmid | 30894403 | - |
dc.identifier.scopus | 2-s2.0-85065519622 | - |
dc.identifier.isi | WOS:000466980400021 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85065519622 | - |
dc.relation.pages | 1670 | en_US |
dc.relation.journalvolume | 218 | en_US |
dc.relation.journalissue | 5 | en_US |
dc.relation.pageend | 1685 | en_US |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Biotechnology | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.orcid | 0000-0002-7295-5004 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 分子醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。