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  4. The interplay between Siglecs and sialylated pathogens
 
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The interplay between Siglecs and sialylated pathogens

Journal
Glycobiology
Journal Volume
24
Journal Issue
9
Pages
818
Date Issued
2014-09
Author(s)
YUNG-CHI CHANG  
Nizet, Victor
DOI
10.1093/glycob/cwu067
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905503889&doi=10.1093%2fglycob%2fcwu067&partnerID=40&md5=5416bd0942626bcbd30c840fc8bfb6af
https://scholars.lib.ntu.edu.tw/handle/123456789/417022
URL
https://api.elsevier.com/content/abstract/scopus_id/84905503889
Abstract
Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors that limit leukocyte activation, and recent research has shown that the pathogen group B Streptococcus (GBS) binds to these Siglecs in Sia- and protein-dependent fashion to downregulate leukocyte bactericidal capacity. Conversely, sialoadhesin is a macrophage phagocytic receptor that engages GBS and other sialylated pathogens to promote effective phagocytosis and antigen presentation for the adaptive immune response. A variety of other important Siglec interactions with bacterial, viral and protozoan pathogens are beginning to be recognized. Siglec genes and binding specificities are rapidly evolving among primates, with key extant polymorphisms in human populations that may influence susceptibility to infection-associated disorders including chronic obstructive pulmonary disease and premature birth. This review summarizes current understanding of interactions between pathogens and Siglecs, a field of investigation that is likely to continue expanding in scope and medical importance.
Subjects
Siglec; bacterial pathogenesis; innate immunity; molecular mimicry, sialic acid
SDGs

[SDGs]SDG3

Publisher
OXFORD UNIV PRESS INC
Type
journal article

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