https://scholars.lib.ntu.edu.tw/handle/123456789/417053
標題: | Assessment of temporal association of relapse of canine multicentric lymphoma with components of the CHOP protocol: Is cyclophosphamide the weakest link? | 作者: | TAI-CHING LIAO Wang, S.-L., Lee, J.-J., Liao, A.T. JIH-JONG LEE SHANG-LIN WANG |
公開日期: | 2016 | 卷: | 213 | 起(迄)頁: | 87-89 | 來源出版物: | Veterinary Journal | 摘要: | Combination chemotherapy, using cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (CHOP), is the most commonly used treatment for canine lymphoma. Most affected dogs respond during the initial stages of chemotherapy, but many relapse. The aim of this study was to evaluate the relationship between the use of specific chemotherapy drugs and clinical relapse, using the modified Madison-Wisconsin, 25 week chemotherapy protocol. Forty-one of 68 dogs affected with multicentric lymphoma relapsed during the treatment period. Relapse occurred more frequently after the administration of cyclophosphamide (n?=?24; P?0.01), compared with vincristine (n?=?9) or doxorubicin (n?=?5). Therefore, the therapeutic outcome of traditional CHOP-based chemotherapy might be improved by replacing cyclophosphamide with other cytotoxic drugs. ? 2016 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991818980&doi=10.1016%2fj.tvjl.2016.04.013&partnerID=40&md5=31d037772107beab017622d420c18bee https://scholars.lib.ntu.edu.tw/handle/123456789/417053 |
DOI: | 10.1016/j.tvjl.2016.04.013 | SDG/關鍵字: | cyclophosphamide; doxorubicin; prednisolone; vincristine; antineoplastic agent; cyclophosphamide; doxorubicin; prednisone; vincristine; Article; cancer combination chemotherapy; controlled study; dog; female; lymphoma; male; nonhuman; retrospective study; Taiwan; tumor recurrence; animal; Dog Diseases; lymphoma; recurrent disease; veterinary; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dog Diseases; Dogs; Doxorubicin; Female; Lymphoma; Male; Prednisone; Recurrence; Vincristine |
顯示於: | 分子暨比較病理生物學研究所 |
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