https://scholars.lib.ntu.edu.tw/handle/123456789/417191
標題: | Serotype competence and penicillin resistance in Streptococcus pneumoniae | 作者: | Hsieh Y.-C. JIN-TOWN WANG Lee W.-S. PO-REN HSUEH PEI-LAN SHAO LUAN-YIN CHANG CHUN-YI LU CHIN-YUN LEE Huang F.-Y. LI-MIN HUANG |
公開日期: | 2006 | 出版社: | Centers for Disease Control and Prevention (CDC) | 卷: | 12 | 期: | 11 | 起(迄)頁: | 1709-1714 | 來源出版物: | Emerging Infectious Diseases | 摘要: | From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750571854&doi=10.3201%2feid1211.060414&partnerID=40&md5=83a801a37bb137d436f6578273a816b7 https://scholars.lib.ntu.edu.tw/handle/123456789/417191 |
ISSN: | 1080-6040 | DOI: | 10.3201/eid1211.060414 | SDG/關鍵字: | penicillin G; peptide derivative; vaccine; antibiotic sensitivity; article; bacterial virulence; bacterium isolation; competence; controlled study; gene cluster; genetic heterogeneity; genetic variability; molecular cloning; nonhuman; penicillin resistance; serotyping; Streptococcus pneumoniae |
顯示於: | 微生物學科所 |
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