https://scholars.lib.ntu.edu.tw/handle/123456789/417229
標題: | Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C | 作者: | Lai M.-Y. JIA-HORNG KAO PEI-MING YANG JIN-TOWN WANG PEI-JER CHEN KIN-WEI CHAN Chu J.- S. DING-SHINN CHEN |
公開日期: | 1996 | 出版社: | W.B. Saunders | 卷: | 111 | 期: | 5 | 起(迄)頁: | 1307-1312 | 來源出版物: | Gastroenterology | 摘要: | Background and Aims: Sustained response to interferon treatment for chronic hepatitis C is unsatisfactory. This study examined whether combining interferon alfa with ribavirin induces a better sustained efficacy than interferon alone in the treatment of chronic hepatitis C. Methods: Sixty noncirrhotic patients with chronic hepatitis C were randomly assigned to three groups. Group 1 received 1200 mg oral ribavirin daily plus 3 million units of recombinant interferon alfa 2a thrice weekly for 24 weeks, group 2 received the same dose of interferon alfa 2a alone for 24 weeks, and group 3 received no treatment. The patients were then followed up for an additional 96 weeks. Results: At the end of treatment, a complete response (normal serum alanine aminotransferase level and undetectable serum hepatitis C virus RNA) was achieved in 16 of the 21 patients in group 1 (76%), as compared with 6 of 19 in group 2 (32%) and none in group 3. At 96 weeks after the end of treatment, patients in group 1 sustained a higher complete response rate than patients in group 2 (43% vs. 6%). Conclusions: Combined treatment with ribavirin and interferon alfa 2a for 24 weeks is more effective than interferon alfa 2a alone for the treatment of chronic hepatitis C. The biochemical and virological responses were sustained in about one half of the treated patients for at least 2 years after cessation of the therapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984533465&doi=10.1053%2fgast.1996.v111.pm8898645&partnerID=40&md5=efb299c5d5a3e7cab9b355a7e17930bd https://scholars.lib.ntu.edu.tw/handle/123456789/417229 |
ISSN: | 0016-5085 | DOI: | 10.1053/gast.1996.v111.pm8898645 | SDG/關鍵字: | alpha2a interferon; recombinant alpha2a interferon; ribavirin; adult; alanine aminotransferase blood level; antiviral activity; article; chronic hepatitis; drug efficacy; female; hepatitis C; human; immunotherapy; intravenous drug administration; major clinical study; male; oral drug administration; priority journal; treatment outcome |
顯示於: | 微生物學科所 |
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