A nested case-control study on the association between helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan
Journal
Anticancer Research
Journal Volume
15
Journal Issue
2
Pages
603-606
Date Issued
1995
Author(s)
Abstract
A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan. A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986. Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by ant enzyme-linked immunosorbent assay. The average interval between serum collection and cancer diagnosis was 3.1 years. Gastric cancer cases had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95% confidence interval = 0.7-2.6). Compared with previous nested case-control studies. Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer. However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.
Subjects
Gastric cancer; Helicobacter pylori; Nested case-control study
SDGs
Other Subjects
immunoglobulin g antibody; adult; age; aged; article; blood sampling; cancer diagnosis; cancer risk; cohort analysis; controlled study; disease association; enzyme linked immunosorbent assay; gender; gram negative infection; helicobacter pylori; housing; human; major clinical study; male; prevalence; priority journal; risk factor; stomach cancer; stomach carcinogenesis; taiwan; Adult; Aged; Antibodies, Bacterial; Case-Control Studies; Child; Cocarcinogenesis; Cohort Studies; Comorbidity; Gastritis; Helicobacter Infections; Helicobacter pylori; Human; Immunoglobulin G; Male; Middle Age; Odds Ratio; Prevalence; Risk; Seroepidemiologic Studies; Stomach Neoplasms; Support, Non-U.S. Gov't; Taiwan; Time Factors
Type
journal article