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  4. Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation
 
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Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation

Journal
Molecular Nutrition and Food Research
Date Issued
2019-01-01
Author(s)
Koh, Yen Chun
Kalyanam, Nagabhushanam
Ho, Chi Tang
MIN-HSIUNG PAN
Li, Shiming
Chen, Pei Yu
Wu, Jia Ching
DOI
10.1002/mnfr.201900514
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/424295
URL
https://api.elsevier.com/content/abstract/scopus_id/85071149944
Abstract
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: A gut-microbiota-dependent metabolite of L-carnitine, trimethylamine-N-oxide (TMAO), has been recently discovered as an independent and dose-dependent risk factor for cardiovascular disease (CVD). This study aims to investigate the effects of pterostilbene on reducing TMAO formation and on decreasing vascular inflammation in carnitine-feeding mice. Methods and results: C57BL/6 mice are treated with 1.3% carnitine in drinking water with or without pterostilbene supplementation. Using LC-MS/MS, the result shows that mice treated with 1.3% carnitine only significantly increased the plasma TMAO and pterostilbene supplementation group can reverse it. Additionally, pterostilbene decreases hepatic flavin monooxygenase 3 (FMO3) mRNA levels compared to carnitine only group. It appears that pterostilbene can alter host physiology and create an intestinal microenvironment favorable for certain gut microbiota. Gut microbiota analysis reveals that pterostilbene increases the abundance of Bacteroides. Further, pterostilbene decreases mRNA levels of vascular inflammatory markers tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin). Conclusion: These data suggest that amelioration of carnitine-induced vascular inflammation after consumption of pterostilbene is partially mediated via modulation of gut microbiota composition and hepatic enzyme FMO3 gene expression.
SDGs

[SDGs]SDG3

Other Subjects
carnitine; dimethylaniline monooxygenase (N-oxide forming); methylamine; oxygenase; pterostilbene; stilbene derivative; trimethyloxamine; tumor necrosis factor; animal; C57BL mouse; female; genetics; intestine flora; metabolism; mouse; oxidation reduction reaction; physiology; vasculitis; Animals; Carnitine; Female; Gastrointestinal Microbiome; Methylamines; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxygenases; Stilbenes; Tumor Necrosis Factor-alpha; Vasculitis
Type
journal article

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