Total synthesis and metabolic stability of hispidulin and its d-labelled derivative
Journal
Molecules
Journal Volume
22
Journal Issue
11
Pages
12314-12324
Date Issued
2017
Author(s)
Abstract
Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To solve these problems, this study developed a novel scheme for synthesizing hispidulin, which had an improved overall yield as well as more concise reaction steps compared to previous methods reported. Additionally, using the same synthetic strategy, d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver microsome. This work may produce new chemical entities for enriching the library of hispidulin-derived compounds.
Publisher
MDPI AG
Type
journal article