Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration
Journal
Molecular medicine (Cambridge, Mass.)
Journal Volume
25
Journal Issue
1
Date Issued
2019
Author(s)
Huang, Yu-Chin
Fu, Ten-I
Abstract
Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the physiological and therapeutic roles of angiopoietin 1 in renal IRI using angiopoietin 1 knockout and over-expression mice.
Subjects
Acute kidney injury; Angiopoietin 1; Endothelium; Ischemic reperfusion injury; Kidney
Publisher
SPRINGER
Type
journal article