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  3. Animal Science and Technology / 動物科學技術學系
  4. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis
 
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Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis

Journal
Evidence-based complementary and alternative medicine : eCAM
Journal Volume
2012
Date Issued
2012
Author(s)
Tsui, Kuan-Hao
Wang, Jyun-Yuan
LEANG-SHIN WU  
CHIH-HSIEN CHIU  
DOI
10.1155/2012/190107
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/425202
URL
https://api.elsevier.com/content/abstract/scopus_id/84862282475
Abstract
Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands. Isocupressic acid (IA) is the component of pine needles responsible for the abortifacient effect, its abortifacient effect may be due to inhibition of steroidogenesis. To investigate the more detail molecular mechanism, we used MA-10 cell, which is wild used to investigate molecular mechanism of steroidogenesis, to characterize the molecular mechanisms underlying the actions of IA in more detail. In this report, we focus on the function of IA on important steroidogenic genes, including steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD). We found that IA does not affect enzyme activities of these genes but inhibits transcription of P450scc and translation of StAR and P450scc through attenuating cAMP-PKA signaling. Thus, steroid productions of cells were suppressed.
SDGs

[SDGs]SDG15

Publisher
HINDAWI LTD
Type
journal article

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