|Title:||Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery||Authors:||Jeong Y.
|Keywords:||cancer therapy;drug delivery;nanocapsule;paclitaxel;sustained drug release||Issue Date:||2016||Journal Volume:||11||Journal Issue:||12||Start page/Pages:||1571-1578||Source:||Nanomedicine||Abstract:||
Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy. ? 2016 Future Medicine Ltd.
|Appears in Collections:||高分子科學與工程學研究所|
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