Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery
Journal
Nanomedicine
Journal Volume
11
Journal Issue
12
Pages
1571-1578
Date Issued
2016
Author(s)
Jeong Y.
Kim S.T.
Jiang Y.
Duncan B.
Kim C.S.
Saha K.
Yeh Y.-C.
Yan B.
Tang R.
Hou S.
Kim C.
Park M.-H.
Rotello V.M.
Abstract
Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy. ? 2016 Future Medicine Ltd.
Subjects
cancer therapy
drug delivery
nanocapsule
paclitaxel
sustained drug release
SDGs
Type
journal article