https://scholars.lib.ntu.edu.tw/handle/123456789/425365| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jeong Y. | en-US |
| dc.contributor.author | Kim S.T. | en-US |
| dc.contributor.author | Jiang Y. | en-US |
| dc.contributor.author | Duncan B. | en-US |
| dc.contributor.author | Kim C.S. | en-US |
| dc.contributor.author | Saha K. | en-US |
| dc.contributor.author | Yeh Y.-C. | en-US |
| dc.contributor.author | Yan B. | en-US |
| dc.contributor.author | Tang R. | en-US |
| dc.contributor.author | Hou S. | en-US |
| dc.contributor.author | Kim C. | en-US |
| dc.contributor.author | Park M.-H. | en-US |
| dc.contributor.author | Rotello V.M. | en-US |
| dc.contributor.author | YI-CHEUN YEH | zz |
| dc.creator | Rotello V.M.;Park M.-H.;Kim C.;Hou S.;Tang R.;Yan B.;Yeh Y.-C.;Saha K.;Kim C.S.;Duncan B.;Jiang Y.;Kim S.T.;Jeong Y.;YI-CHEUN YEH | - |
| dc.date.accessioned | 2019-09-26T08:31:11Z | - |
| dc.date.available | 2019-09-26T08:31:11Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.issn | 17435889 | - |
| dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/425365 | - |
| dc.description.abstract | Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy. ? 2016 Future Medicine Ltd. | - |
| dc.language | English | - |
| dc.relation.ispartof | Nanomedicine | - |
| dc.subject | cancer therapy | - |
| dc.subject | drug delivery | - |
| dc.subject | nanocapsule | - |
| dc.subject | paclitaxel | - |
| dc.subject | sustained drug release | - |
| dc.title | Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery | en_US |
| dc.type | journal article | - |
| dc.identifier.doi | 10.2217/nnm-2016-0034 | - |
| dc.identifier.scopus | 2-s2.0-84977495829 | - |
| dc.identifier.url | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84977495829&doi=10.2217%2fnnm-2016-0034&partnerID=40&md5=7e041d0edb4eef737a420bdf5e7d2069 | - |
| dc.relation.pages | 1571-1578 | - |
| dc.relation.journalvolume | 11 | - |
| dc.relation.journalissue | 12 | - |
| item.grantfulltext | none | - |
| item.openairetype | journal article | - |
| item.fulltext | no fulltext | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
| item.cerifentitytype | Publications | - |
| crisitem.author.dept | Polymer Science and Engineering | - |
| crisitem.author.parentorg | College of Engineering | - |
| Appears in Collections: | 高分子科學與工程學研究所 | |
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