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  4. Djulis (Chenopodium Formosanum) Prevents Colon Carcinogenesis via Regulating Antioxidative and Apoptotic Pathways in Rats
 
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Djulis (Chenopodium Formosanum) Prevents Colon Carcinogenesis via Regulating Antioxidative and Apoptotic Pathways in Rats

Journal
Nutrients
Journal Volume
11
Journal Issue
9
Date Issued
2019-09-10
Author(s)
Xie, Gui Ru
HONG-JHANG CHEN  
Lee, Chih Wei
Shih, Chun Kuang
DOI
10.3390/nu11092168
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/425806
URL
https://api.elsevier.com/content/abstract/scopus_id/85072140947
Abstract
Djulis is a cereal crop rich in polyphenols and dietary fiber that may have nutraceutical activity to prevent colon cancer. This study was designed to examine the preventive effect of djulis on colon carcinogenesis in rats treated with 1,2-dimethylhydrazine (DMH). Rats were fed different AIN-93G-based diets: groups N and DMH were fed AIN-93G diet and groups LD, MD, and HD were fed AIN-93G diet containing 5, 10, and 20% djulis, respectively. All rats except for group N were injected with DMH to induce colon carcinogenesis. After 10 weeks, rats were sacrificed and colon and liver tissues were collected for analysis. The results showed that djulis-treated rats had significantly lower numbers of colonic preneoplastic lesions, aberrant crypt foci (ACF), sialomucin-producing (SIM)-ACF, and mucin-depleted foci. Djulis treatment increased superoxide dismutase and catalase activities in colon and liver. Djulis also reduced p53, Bcl-2, and proliferating cell nuclear antigen expressions and increased Bax and caspase-9 expressions. Besides, phenolic compounds and flavonoids were found rich in djulis. These results demonstrate the chemopreventive effect of djulis on carcinogen-induced colon carcinogenesis via regulating antioxidative and apoptotic pathways in rats. Djulis may have the potential to be developed as a valuable cereal product for chemoprevention of colon cancer.
Subjects
antioxidant | apoptosis | chemoprevention | colon cancer | djulis | preneoplastic lesions
SDGs

[SDGs]SDG3

Other Subjects
1,1 dimethylhydrazine; antioxidant; caspase 9; catalase; flavonoid; nutraceutical; polyphenol; protein Bax; protein bcl 2; protein p53; sialomucin; superoxide dismutase; aberrant crypt focus; animal experiment; animal tissue; antioxidant assay; apoptosis; Article; bakery product; cancer growth; cell proliferation; Chenopodium Formosanum; colon carcinogenesis; dietary fiber; male; nonhuman; protein expression; rat; Western blotting
Type
journal article

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