https://scholars.lib.ntu.edu.tw/handle/123456789/425890
標題: | Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder | 作者: | Lo, Yu Chun YU-JEN CHEN Hsu, Yung Chin WEN-YIH TSENG SUSAN SHUR-FEN GAU |
關鍵字: | Autism spectrum disorders | brain imaging | communication | 公開日期: | 1-五月-2017 | 卷: | 58 | 期: | 5 | 起(迄)頁: | 576 | 來源出版物: | Journal of Child Psychology and Psychiatry and Allied Disciplines | 摘要: | © 2016 Association for Child and Adolescent Mental Health. Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social communication deficits as one of the core symptoms. Recently, a five-level model for the social communication has been proposed in which white matter tracts corresponding to each level of the model are identified. Given that the model for social communication subserves social language functions, we hypothesized that the tract integrity of the model for social communication may be reduced in ASD, and the reduction may be related to social communication deficits. Methods: Sixty-two right-handed boys with ASD and 55 typically developing (TD) boys received clinical evaluations, intelligence tests, the Social Communication Questionnaire (SCQ), and MRI scans. Generalized fractional anisotropy (GFA) was measured by diffusion spectrum imaging to indicate the microstructural integrity of the tracts for each level of the social communication model. Group difference in the tract integrity and its relationship with the SCQ subscales of social communication and social interaction were investigated. Results: We found that the GFA values of the superior longitudinal fasciculus III (SLF III, level 1) and the frontal aslant tracts (FAT, level 2) were decreased in ASD compared to TD. Moreover, the GFA values of the SLF III and the FAT were associated with the social interaction subscale in ASD. Conclusions: The tract integrity of the model for social communication is reduced in ASD, and the reduction is associated with impaired social interaction. Our results support that reduced tract integrity of the model for social communication might be a neural substrate of social communication deficits in ASD. |
URI: | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84990862331&doi=10.1111%2fjcpp.12641&partnerID=40&md5=55a18892e742d205e2bdbec203596066 https://scholars.lib.ntu.edu.tw/handle/123456789/425890 |
ISSN: | 00219630 | DOI: | 10.1111/jcpp.12641 |
顯示於: | 醫療器材與醫學影像研究所 |
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