Relationship Between Statin Use and Outcomes in Patients Having Cardiac Arrest (from a Nationwide Cohort Study in Taiwan)
Journal
The American journal of cardiology
Journal Volume
123
Journal Issue
10
Pages
1572
Date Issued
2019-05-15
Author(s)
Yu, Ping-Hsun
Tang, Chao-Hsiun
CHIEN-HUA HUANG
Yu, Ping-Hsun
MIN-SHAN TSAI
HUI-CHUN HUANG
TZUNG-DAU WANG
WEI-TIEN CHANG
Tang, Chao-Hsiun
WEN-JONE CHEN
Abstract
Pretreatment with statins is associated with improved outcomes in severe sepsis, acute coronary syndrome, and stroke. Patients with cardiac arrest experience sepsis-like syndrome and ischemia reperfusion injuries in the heart and brain. The objective of this study was to investigate the effects of statin use before cardiac arrest on outcomes in cardiac arrest patients. Medical records of 142,131 adult patients who experienced nontraumatic cardiac arrest and were resuscitated between 2004 and 2011 were analyzed. Patients were grouped into 2 groups: the "statin group" comprised patients who had received statin treatment for at least 30 days before the cardiac arrest event; the "never statin group" comprised patients who had no statin use within 30 days before the event. Patients with previous statin treatment had better chance of survival to hospital discharge (6.1% vs 4.3%, p <0.0001) and 1-year survival (4.8% vs 3.2%, p <0.0001) after propensity score matching. Previous statin use was an independent predictor for 1-year survival (adjusted odds ratio 1.41, 95% confidence interval 1.16 to 1.71; p = 0.001). A favorable outcome effect of statin on 1-year survival was observed in the presence of diabetes mellitus, chronic kidney disease, and Charlson Comorbidity Index score greater than 5 in the subgroup analysis. In conclusion, statin use before cardiac arrest is associated with 1-year survival in a propensity score-matched nationwide cohort study.
SDGs
Other Subjects
hydroxymethylglutaryl coenzyme A reductase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; aged; Article; Charlson Comorbidity Index; chronic kidney failure; cohort analysis; controlled study; diabetes mellitus; drug effect; female; heart arrest; hospital discharge; human; independent variable; major clinical study; male; medical record; observational study; predictor variable; priority journal; propensity score; resuscitation; retrospective study; survival rate; Taiwan; treatment duration; treatment outcome; clinical trial; complication; follow up; heart arrest; heart muscle ischemia; incidence; multicenter study; propensity score; register; Aged; Female; Follow-Up Studies; Heart Arrest; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Myocardial Ischemia; Propensity Score; Registries; Retrospective Studies; Survival Rate; Taiwan
Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Type
journal article