https://scholars.lib.ntu.edu.tw/handle/123456789/426872
標題: | Measurement of cerebral white matter perfusion using pseudocontinuous arterial spin labeling 3T magneticresonance imaging - An experimental and theoretical investigation of feasibility | 作者: | Wu Wen-Chau Lin S.-C Wang D.J Chen K.-L Li Y.-D. |
公開日期: | 2013 | 卷: | 8 | 期: | 12 | 來源出版物: | PLoS ONE | 摘要: | Purpose: This study was aimed to experimentally and numerically investigate the feasibility of measuring cerebral white matter perfusion using pseudocontinuous arterial spin labeling (PCASL) 3T magnetic resonance imaging (MRI) at a relatively fine resolution to mitigate partial volume effect from gray matter. Materials and Methods: The Institutional Research Ethics Committee approved this study. On a clinical 3T MR system, ten healthy volunteers (5 females, 5 males, age = 28±3 years) were scanned after providing written informed consent. PCASL imaging was performed with varied combinations of labeling duration (τ = 1000, 1500, 2000, and 2500 ms) and post-labeling delay (PLD = 1000, 1400, 1800, and 2200 ms), at a spatial resolution (1.56×1.56×5 mm3) finer than commonly used (3.5×3.5 mm2, 5-8 mm in thickness). Computer simulations were performed to calculate the achievable perfusion-weighted signal-to-noise ratio at varied τ, PLD, and transit delay.Results: Based on experimental and numerical data, the optimal τ and PLD were found to be 2000 ms and 1500-1800 ms, respectively, yielding adequate SNR (?2) to support perfusion measurement in the majority (?60%) of white matter. The measurement variability was about 9% in a one-week interval. The measured white matter perfusion and perfusion ratio of gray matter to white matter were 15.8-27.5 ml/100ml/min and 1.8-4.0, respectively, depending on spatial resolution as well as the amount of deep white matter included. Conclusion: PCASL 3T MRI is able to measure perfusion in the majority of cerebral white matter at an adequate signal-to-noise ratio by using appropriate tagging duration and post-labeling delay. Although pixel-wise comparison may not be possible, region-of-interest based flow quantification is feasible. ? 2013 Wu et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891910738&doi=10.1371%2fjournal.pone.0082679&partnerID=40&md5=1ddf13f6ce523d75794aebc95dcc8e5c https://scholars.lib.ntu.edu.tw/handle/123456789/426872 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0082679 | SDG/關鍵字: | adult; article; brain function; brain perfusion; brain region; brain size; cohort analysis; computer simulation; controlled study; feasibility study; female; functional assessment; gray matter; human; human experiment; image analysis; male; mathematical computing; neuroimaging; nuclear magnetic resonance imaging; perfusion weighted imaging; pseudocontinuous arterial spin labeling; quantitative analysis; reliability; signal noise ratio; spin labeling; three dimensional imaging; white matter; Adult; Brain; Cerebrovascular Circulation; Computer Simulation; Female; Healthy Volunteers; Humans; Magnetic Resonance Angiography; Male; Reproducibility of Results; Signal-To-Noise Ratio; Spin Labels; Time Factors |
顯示於: | 醫療器材與醫學影像研究所 |
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