https://scholars.lib.ntu.edu.tw/handle/123456789/426875
標題: | Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI | 作者: | Pinkham A Loughead J Ruparel K Wu Wen-Chau Overton E Gur R Gur R. |
關鍵字: | ASL fMRI; Middle frontal gyrus; Negative symptoms; Positive symptoms; Superior temporal gyrus; White matter | 公開日期: | 2011 | 卷: | 194 | 期: | 1 | 起(迄)頁: | 64-72 | 來源出版物: | Psychiatry Research - Neuroimaging | 摘要: | Arterial spin labeling (ASL) perfusion MRI is a relatively novel technique that can allow for quantitative measurement of cerebral blood flow (CBF) by using magnetically labeled arterial blood water as an endogenous tracer. Available data on resting CBF in schizophrenia primarily come from invasive and expensive nuclear medicine techniques that are often limited to small samples and yield mixed results. The noninvasive nature of ASL offers promise for larger-scale studies. The utility of this approach was examined in 24 healthy controls and 30 patients with schizophrenia. Differences between groups in quantitative CBF were assessed, as were relationships between CBF and psychiatric symptoms. Group comparisons demonstrated greater CBF for controls in several regions including bilateral precuneus and middle frontal gyrus. Patients showed increased CBF in left putamen/superior corona radiata and right middle temporal gyrus. For patients, greater severity of negative symptoms was associated with reduced CBF in bilateral superior temporal gyrus, cingulate gyrus, and left middle frontal gyrus. Increased severity of positive symptoms was related to both higher CBF in cingulate gyrus and superior frontal gyrus and decreased CBF in precentral gyrus/middle frontal gyrus. These findings support the feasibility and utility of implementing ASL in schizophrenia research and expand upon previous results. ? 2011 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053383462&doi=10.1016%2fj.pscychresns.2011.06.013&partnerID=40&md5=39130b5a7399b4d5841c8f05da734c06 https://scholars.lib.ntu.edu.tw/handle/123456789/426875 |
ISSN: | 0925-4927 | DOI: | 10.1016/j.pscychresns.2011.06.013 | SDG/關鍵字: | adult; arterial spin labeling perfusion magnetic resonance imaging; article; brain blood flow; cingulate gyrus; clinical article; controlled study; female; human; male; middle frontal gyrus; perfusion weighted imaging; precuneus; priority journal; schizophrenia; superior temporal gyrus; symptomatology; Adult; Arteries; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Perfusion; Psychiatric Status Rating Scales; Rest; Schizophrenia; Spin Labels |
顯示於: | 醫療器材與醫學影像研究所 |
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