A three-dimensional cell culture device for simulation of hepatic hypertension
Journal
The 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Date Issued
2017
Author(s)
Hao-Dinh Phung
Abstract
Hepatic stellate cells (HSCs) play a crucial role in the development of liver fibrosis which is characterized by massive tissue scarring, elevated hepatic sinusoidal pressure, and portal hypertension. However, while a multitude of chemical factors have been investigated in the pathogenesis of liver fibrosis, physical factors such as elevated hydrostatic pressure and shear stress caused by blood flow in sinusoids remain unclear. In this study, we developed a three-dimensional (3D) cell culture microfluidic platform that mimics the physical environments of hepatic sinusoids to investigate the effects of elevated hydrostatic pressure on HSCs phenotypes. © 2017 IEEE.
Other Subjects
cell culture technique; hepatic stellate cell; human; hypertension; liver; liver cirrhosis; portal hypertension; Cell Culture Techniques; Hepatic Stellate Cells; Humans; Hypertension; Hypertension, Portal; Liver; Liver Cirrhosis
Type
conference paper