Feasibility and safety of a novel magnetic-assisted capsule endoscope system in a preliminary examination for upper gastrointestinal tract
Journal
Surgical Endoscopy
Journal Volume
32
Journal Issue
4
Pages
85314
Date Issued
2018
Author(s)
Abstract
Background and study aim: Current capsule endoscopy procedures are ineffective for upper gastrointestinal (GI) tract examination because they do not allow for operator-controlled navigation of the capsule. External controllability of a capsule endoscope with an applied magnetic field is a possible solution to this problem. We developed a novel magnetic-assisted capsule endoscope (MACE) system to visualize the entire upper GI tract. The present study evaluated the safety and feasibility of the MACE system for the examination of the upper GI tract, including the esophagus, stomach, and duodenum. Methods: The present open clinical study enrolled ten healthy volunteers. All participants swallowed a MACE, and an external magnetic field navigator was used for magnetic capsule manipulation in the upper GI tract. We assessed the maneuverability of the magnetic capsule and completeness of the MACE examination as well as the safety and tolerability of the procedure. Results: The present study enrolled ten healthy volunteers with a mean age and body mass index of 47.7?years and 25.6?kg/m2, respectively. One volunteer withdrew because of difficulty in swallowing the capsule. In total, nine volunteers underwent the MACE examination. The average examination time was 27.1?min. The maneuverability of the capsule was assessed as good and fair in 55.6 and 44.4% of the participants, respectively. The overall completeness of the examination in the esophagus, stomach, and duodenum was 100, 85.2, and 86.1%, respectively. No severe adverse events occurred during this study. All participants exhibited satisfactory tolerance of the MACE examination. Conclusion: The MACE system has satisfactory maneuverability and visualization completeness with excellent acceptance and tolerance. ? 2017, Springer Science+Business Media, LLC.
Subjects
Capsule endoscope; Duodenum; Esophagus; Stomach
SDGs
Other Subjects
adult; age; Article; body mass; device safety; digestive system examination; duodenum; epigastric discomfort; esophagus; feasibility study; female; human; human experiment; lens; magnetic field; male; nausea; normal human; patient satisfaction; priority journal; stomach; stomach distension; upper gastrointestinal tract; aged; capsule endoscope; capsule endoscopy; devices; diagnostic imaging; equipment design; magnetism; middle aged; upper gastrointestinal tract; young adult; Adult; Aged; Capsule Endoscopes; Capsule Endoscopy; Equipment Design; Feasibility Studies; Female; Healthy Volunteers; Humans; Magnetics; Male; Middle Aged; Upper Gastrointestinal Tract; Young Adult
Type
journal article