https://scholars.lib.ntu.edu.tw/handle/123456789/429962
標題: | Influence of amplitude-related perfusion parameters of parotid glands by non-fat-saturated dynamic contrast-enhanced magnetic resonance imaging | 作者: | Chiu SC Cheng CC Chang HC Chung HW Chiu HC Liu YJ Hsu HH Juan CJ HSIAO-WEN CHUNG |
關鍵字: | Dynamic contrast-enhanced magnetic resonance imaging; Fat content; Parotid gland; Perfusion; Pharmacokinetic model | 公開日期: | 2016 | 卷: | 43 | 起(迄)頁: | 74-83 | 來源出版物: | Medical Physics | 摘要: | Purpose: To verify whether quantification of parotid perfusion is affected by fat signals on non-fatsaturated (NFS) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and whether the influence of fat is reduced with fat saturation (FS). Methods: This study consisted of three parts. First, a retrospective study analyzed DCE-MRI data previously acquired on different patients using NFS (n = 18) or FS (n = 18) scans. Second, a phantom study simulated the signal enhancements in the presence of gadolinium contrast agent at six concentrations and three fat contents. Finally, a prospective study recruited nine healthy volunteers to investigate the influence of fat suppression on perfusion quantification on the same subjects. Parotid perfusion parameters were derived from NFS and FS DCE-MRI data using both pharmacokinetic model analysis and semiquantitative parametric analysis. T tests and linear regression analysis were used for statistical analysis with correction for multiple comparisons. Results: NFS scans showed lower amplitude-related parameters, including parameter A, peak enhancement (PE), and slope than FS scans in the patients (all with P < 0.0167). The relative signal enhancement in the phantoms was proportional to the dose of contrast agent and was lower in NFS scans than in FS scans. The volunteer study showed lower parameter A (6.75±2.38 a.u.), PE (42.12%±14.87%), and slope (1.43%±0.54% s-1) in NFS scans as compared to 17.63±8.56 a.u., 104.22%±25.15%, and 9.68%±1.67% s-1, respectively, in FS scans (all with P < 0.005). These amplitude-related parameters were negatively associated with the fat content in NFS scans only (all with P < 0.05). Conclusions: On NFS DCE-MRI, quantification of parotid perfusion is adversely affected by the presence of fat signals for all amplitude-related parameters. The influence could be reduced on FS scans. ? 2016 American Association of Physicists in Medicine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/429962 | ISSN: | 942405 | DOI: | 10.1118/1.4943798 | SDG/關鍵字: | Magnetism; Phantoms; Pharmacokinetics; Regression analysis; Resonance; Dynamic contrast enhanced magnetic resonance imaging; Fat contents; Parotid glands; Perfusion; Pharmacokinetic model; Magnetic resonance imaging; gadolinium pentetate; adult; adverse outcome; aged; Article; concentration (parameters); contrast enhancement; controlled study; dynamic contrast-enhanced magnetic resonance imaging; fat content; female; human; human experiment; image analysis; image processing; imaging phantom; imaging software; intermethod comparison; limit of quantitation; male; middle aged; normal human; nuclear magnetic resonance scanner; organ perfusion; organs at risk; parotid gland; parotid perfusion; prospective study; quantitative analysis; retrospective study; signal detection; young adult; blood flow; diagnostic imaging; nuclear magnetic resonance imaging; parotid gland; procedures; vascularization; Adult; Aged; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Parotid Gland; Phantoms, Imaging; Regional Blood Flow; Young Adult |
顯示於: | 生醫電子與資訊學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。