https://scholars.lib.ntu.edu.tw/handle/123456789/429973
標題: | Histogram analysis of T2*-based pharmacokinetic imaging in cerebral glioma grading | 作者: | Liu HS Chiang SW Chung HW Tsai PH Hsu FT Cho NY Wang CY Chou MC Chen CY HSIAO-WEN CHUNG |
關鍵字: | Cerebral glioma; Histogram analysis; Permeability imaging; Tumor grading | 公開日期: | 2018 | 卷: | 155 | 起(迄)頁: | 116009 | 來源出版物: | Computer Methods and Programs in Biomedicine | 摘要: | Background and objective To investigate the feasibility of histogram analysis of the T2*-based permeability parameter volume transfer constant (Ktrans) for glioma grading and to explore the diagnostic performance of the histogram analysis of Ktrans and blood plasma volume (vp). Methods We recruited 31 and 11 patients with high- and low-grade gliomas, respectively. The histogram parameters of Ktrans and vp, derived from the first-pass pharmacokinetic modeling based on the T2* dynamic susceptibility-weighted contrast-enhanced perfusion-weighted magnetic resonance imaging (T2* DSC-PW-MRI) from the entire tumor volume, were evaluated for differentiating glioma grades. Results Histogram parameters of Ktrans and vp showed significant differences between high- and low-grade gliomas and exhibited significant correlations with tumor grades. The mean Ktrans derived from the T2* DSC-PW-MRI had the highest sensitivity and specificity for differentiating high-grade gliomas from low-grade gliomas compared with other histogram parameters of Ktrans and vp. Conclusions Histogram analysis of T2*-based pharmacokinetic imaging is useful for cerebral glioma grading. The histogram parameters of the entire tumor Ktrans measurement can provide increased accuracy with additional information regarding microvascular permeability changes for identifying high-grade brain tumors. ? 2017 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/429973 | ISSN: | 1692607 | DOI: | 10.1016/j.cmpb.2017.11.011 | SDG/關鍵字: | Diagnosis; Grading; Graphic methods; Magnetic resonance imaging; Magnetic susceptibility; Pharmacokinetics; Cerebral gliomas; Diagnostic performance; Dynamic susceptibility; High-grade gliomas; Histogram analysis; Permeability change; Pharmacokinetic model; Sensitivity and specificity; Tumors; adult; Article; body height; cancer diagnosis; cancer grading; clinical article; comparative study; controlled study; diagnostic accuracy; diagnostic test accuracy study; female; first pass effect; glioma; histogram; human; male; middle aged; perfusion weighted imaging; pharmacokinetic parameters; plasma volume; retrospective study; sensitivity and specificity; susceptibility weighted imaging; tumor volume; aged; blood brain barrier; brain tumor; cancer grading; capillary permeability; diagnostic imaging; glioma; neovascularization (pathology); nuclear magnetic resonance imaging; pathology; procedures; vascularization; very elderly; contrast medium; Adult; Aged; Aged, 80 and over; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Contrast Media; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Neovascularization, Pathologic; Retrospective Studies; Sensitivity and Specificity |
顯示於: | 生醫電子與資訊學研究所 |
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