Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS
Journal
Journal of Analytical Toxicology
Journal Volume
26
Journal Issue
5
Pages
286-295
Date Issued
2002
Author(s)
Abstract
Mercury contents in biological samples can be measured by cold vapor atomic absorption spectroscopy combined with the flow-injection analysis system. However, water vapor in the absorption cell attenuated and distorted the signals. This study described the strategy to overcome this problem by adding an additional gas-liquid separator after the mixing/separator assembly. This modification can efficiently minimize the moisture in the transfer line and in the absorption cell. This improved technique was adopted to study the differential tissue distribution of methylmercury and HgS after oral administration to mice for five consecutive days. The present study suggests that the insoluble HgS (the main constituent of a Chinese mineral drug, cinnabar, used as a sedative) can still be absorbed from gastrointestinal tract and distributed to various tissues including the brain. As compared with methylmercury, the total amount of HgS accumulated in the tissues ranging about one five-thousandth of methylmercury, which is well correlated with the biological activity of HgS reported previously.
SDGs
Other Subjects
mercury; mercury sulfide; methylmercury; mercury derivative; absorption; animal experiment; animal model; animal tissue; article; atomic absorption spectrometry; chemical modification; controlled study; diagnostic accuracy; drug absorption; drug activity; drug tissue level; flow injection analysis; mercurialism; mouse; neurotoxicity; nonhuman; sensitivity and specificity; tissue distribution; animal; gas; Institute for Cancer Research mouse; male; methodology; oral drug administration; volatilization; Animalia; Administration, Oral; Animals; Gases; Male; Mercury Compounds; Mice; Mice, Inbred ICR; Spectrophotometry, Atomic; Tissue Distribution; Volatilization
Publisher
Preston Publications
Type
journal article