Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma
Journal
Journal of the Formosan Medical Association = Taiwan yi zhi
Journal Volume
117
Journal Issue
3
Pages
212
Date Issued
2018-03
Author(s)
Abstract
Deregulation of metabolic pathways is one of the hallmarks of cancer progression. Connective tissue growth factor (CTGF/CCN2) acts as a tumor suppressor in oral squamous cell carcinoma (OSCC). However, the role of CTGF in modulating cancer metabolism is still unclear.
Subjects
CTGF; Metabolism; Mitochondrion; OSCC; mtTFA
Other Subjects
adenosine triphosphate; benzyloxycarbonylleucylleucylleucinal; connective tissue growth factor; mitochondrial DNA; mitochondrial transcription factor A; short hairpin RNA; ubiquitin; ubiquitinated protein; connective tissue growth factor; DNA binding protein; mitochondrial protein; mitochondrial transcription factor A; transcription factor; ubiquitin; acidification; Article; cell invasion; cell migration; copy number variation; glycolysis; immunoprecipitation; mitochondrial biogenesis; mitochondrial respiration; mouth squamous cell carcinoma; oxygen consumption; protein expression; real time polymerase chain reaction; SAS cell line; Western blotting; human; metabolism; mitochondrion; mouth tumor; physiology; squamous cell carcinoma; tumor cell line; Carcinoma, Squamous Cell; Cell Line, Tumor; Connective Tissue Growth Factor; DNA-Binding Proteins; Humans; Mitochondria; Mitochondrial Proteins; Mouth Neoplasms; Transcription Factors; Ubiquitin
Publisher
ELSEVIER TAIWAN
Type
journal article