Ultrashort antimicrobial peptides with antiendotoxin properties
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
59
Journal Issue
8
Pages
5052-5056
Date Issued
2015
Author(s)
Chih, Ya-Han; Lin, Yen-Shan; Wei, Hsiu-Ju; Chu, Hung-Lun; Yu, Hui-Yuan; Cheng, Hsi-Tsung; Chou, Yu-Ting; Cheng, Jya-Wei
Abstract
Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK.
Type
journal article