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  4. Alternative approach for selected severe pulmonary hypertension of congenital heart defect without initial correction - Palliative surgical treatment
 
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Alternative approach for selected severe pulmonary hypertension of congenital heart defect without initial correction - Palliative surgical treatment

Journal
International Journal of Cardiology
Journal Volume
151
Journal Issue
3
Pages
313-317
Date Issued
2011
Author(s)
MING-TAI LIN  
YIH-SHARNG CHEN  
SHU-CHIEN HUANG  
Chiu H.-H.
SHUENN-NAN CHIU  
CHUN-AN CHEN  
EN-TING WU  
ING-SH CHIU  
CHUNG-I CHANG  
MEI-HWAN WU  
JOU-KOU WANG  
DOI
10.1016/j.ijcard.2010.05.067
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052768997&doi=10.1016%2fj.ijcard.2010.05.067&partnerID=40&md5=119b3e63ed73da15d8bb55be9c0795e3
https://scholars.lib.ntu.edu.tw/handle/123456789/434064
Abstract
Objectives: Uncorrected congenital heart defects (CHD) with severe pulmonary hypertension (sPH, systolic pulmonary artery > 70% of systolic pressure) are usually considered inoperable. We are curious to know if some selected patients might benefit from palliative operation for those sPH with uncorrected CHD. Methods: Adults or adolescents with sPH associated with ventricular septal defect (VSD) with/without great artery anomalies were selected for pulmonary artery banding (PAB) to reduce sPH. The target pulmonary pressure was less than half of the systolic blood pressure after arch or great arteries reconstruction. Repeated catheterization was performed to evaluate the feasibility of defect closure. Results: Consecutively, 8 patients (age 26 ± 9 years) received PAB as a palliative procedure in the past 8 years without mortality. The pre-PAB systolic pulmonary pressure was 119 ± 9 mmHg. Additional PAB had been applied in 4 of them. All patients showed significant improvement in function class (III to I or II). The mean post-PAB pulmonary pressure decreased significantly (77.5 ± 9.2 mmHg to 42.0 ± 9.0 mmHg) and 6-minute walk test was also found to have great improvement (270 ± 86 m to 414 ± 49 m), but the saturation at rest did not show a difference. Three of them received corrective surgery to close defects over 3-5 years. Conclusion: For some selected adult sPH with uncorrected CHD, PAB can work as a palliative procedure to improve their functional class and even provide a chance of total repair. ? 2010 Elsevier Ireland Ltd. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
adolescent; adult; artery malformation; artery reconstruction; article; clinical article; controlled study; disease association; disease classification; disease severity; exercise test; feasibility study; female; heart catheterization; heart left right shunt; heart ventricle septum defect; hemodynamics; human; human tissue; lung artery banding; lung biopsy; lung pressure; lung vascular resistance; male; mortality; outcome assessment; oxygen saturation; palliative therapy; patient selection; priority journal; pulmonary hypertension; six minute walk test; systolic blood pressure; Adolescent; Adult; Female; Heart Catheterization; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Male; Palliative Care; Severity of Illness Index; Treatment Outcome; Vascular Surgical Procedures; Young Adult
Type
journal article

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