The role of mechanical-electrical interaction in ventricular arrhythmia: Evidence from a novel animal model for repaired tetralogy of Fallot
Journal
Pediatric Research
Journal Volume
70
Journal Issue
3
Pages
247-252
Date Issued
2011
Author(s)
Chang C.-W.
Chen H.-C.
Abstract
Pulmonary regurgitation and prolonged QRS duration of right bundle branch (RBB) block are common in repaired tetralogy of Fallot (TOF) and increase the risk of sudden death. We sought to establish an animal model to reflect both abnormalities. Twenty-one canines: group I (n = 7) received a surgical right ventricular outflow tract (RVOT) transannular patch plus pulmonary valve destruction; group II (n = 5) received RBB ablation and sham operation; and group III (n = 9) received combined interventions. Serial electrophysiological data were obtained up to 1 y. Procedure mortality was 27.6%. At 1 y, although severe pulmonary regurgitation was documented in most dogs in groups I (71%) and III (100%), progressive RVOT dilatation was noted in group III. RBB block was present in all dogs in groups II and III. However, the increments of QRS duration, QTc, JTc, and QT dispersion progression between 1 mo and 1 y were all greatest in group III. Ventricular arrhythmia events were frequent in group III (median 3.3/mo) but uncommon in groups I and II (median 1/mo). We have created a novel animal model that adequately reflects both the hemodynamic and electrophysiological characteristics of repaired TOF patients and can be applied to examine the risk of ventricular arrhythmias. ABBREVIATION: Copyright ? 2011 International Pediatric Research Foundation, Inc.
SDGs
Other Subjects
ablation therapy; animal experiment; animal model; article; blood pressure; controlled study; disease course; disease severity; dog; electrocardiography; experimental model; Fallot tetralogy; heart electrophysiology; heart hemodynamics; heart rate; heart right bundle branch block; heart right ventricle outflow tract; heart ventricle arrhythmia; heart ventricle enddiastolic pressure; lung artery pressure; nonhuman; pericardium; priority journal; pulmonary valve; pulmonary valve insufficiency; QRS complex; QT dispersion; sham procedure; Animals; Arrhythmias, Cardiac; Bundle-Branch Block; Death, Sudden, Cardiac; Dogs; Electrocardiography; Heart Conduction System; Heart Ventricles; Hemodynamics; Humans; Pulmonary Valve Insufficiency; Tetralogy of Fallot
Type
journal article