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  4. Extracorporeal membrane oxygenation rescue for cardiopulmonary resuscitation in pediatric patients
 
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Extracorporeal membrane oxygenation rescue for cardiopulmonary resuscitation in pediatric patients

Journal
Critical Care Medicine
Journal Volume
36
Journal Issue
5
Pages
1607-1613
Date Issued
2008
Author(s)
SHU-CHIEN HUANG  
EN-TING WU  
YIH-SHARNG CHEN  
CHUNG-I CHANG  
ING-SH CHIU  
SHOEI-SHEN WANG  
Lin F.-Y.
Ko W.-J.
DOI
10.1097/CCM.0b013e318170b82b
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-42949115926&doi=10.1097%2fCCM.0b013e318170b82b&partnerID=40&md5=c765c4e445ff3096fe03070a980825b8
https://scholars.lib.ntu.edu.tw/handle/123456789/434126
Abstract
OBJECTIVE: To describe survival and neurologic outcome and identify the factors associated with survival among pediatric patients following extracorporeal cardiopulmonary resuscitation (ECPR) for in-hospital cardiac arrest. DESIGN: Retrospective study. SETTING: A university-affiliated tertiary care hospital. PATIENTS: Eligible patients were ?18 yrs of age and received extracorporeal membrane oxygenation during active cardiopulmonary resuscitation for in-hospital cardiac arrest. INTERVENTIONS: Extracorporeal membrane oxygenation (ECMO) during active cardiopulmonary resuscitation. MEASUREMENTS AND MAIN RESULTS: The primary outcome was survival to hospital discharge. The secondary outcome was neurologic status after ECPR at hospital discharge and late follow-up. Good neurologic outcome was defined as Pediatric Cerebral Performance Categories 1, 2, and 3. Continuous variables were expressed as medians (interquartile range). We prospectively defined the early cohort (January 1999 to December 2001) and late cohort (January 2002 to January 2006) and compared the survival rates. We identified 27 ECPR events. The survival rate to hospital discharge was 41% (11 of 27). The nonsurvivors had higher pre-cardiopulmonary resuscitation serum lactate levels (14 [10.2-19.6] mmol/L vs. 8.5 [4.4-12.6] mmol/L, p < .01), longer durations of cardiopulmonary resuscitation (60 [37-81] mins vs. 45 [25-50] mins, p < .05) with longer activating time for ECMO (12.5 [7.5-33.8] mins vs. 5 [0-10] mins, p < .01), and more renal failure after ECPR (68% [11 of 16] vs. 9% [1 of 11], p < .01). The survival rate of the late cohort was better than that of the early cohort (58% [11 of 19] vs. 0% [0 of 8], p < .05). By exact multiple logistic regression analysis, the early cohort and renal failure after ECPR were two independent risk factors for mortality. Among the 11 survivors, ten had good neurologic outcomes. CONCLUSIONS: ECPR successfully rescued some pediatric patients who failed rescue with conventional in-hospital CPR. Good neurologic outcomes were achieved in the majority of the survivors. Early cohort and post-ECPR renal failure were associated with mortality. ? 2008 Lippincott Williams & Wilkins, Inc.
SDGs

[SDGs]SDG3

Other Subjects
lactic acid; adolescent; article; cannula; child; child care; clinical article; extracorporeal oxygenation; female; follow up; heart arrest; hospital discharge; hospitalization; human; infant; intensive care unit; kidney failure; lactate blood level; male; mortality; neurologic disease; newborn; priority journal; resuscitation; risk factor; survival rate; tertiary health care; treatment duration; treatment outcome
Publisher
Lippincott Williams and Wilkins
Type
journal article

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