https://scholars.lib.ntu.edu.tw/handle/123456789/434712
標題: | Dapsone hypersensitivity syndrome in non-leprosy patients: A retrospective study of its incidence in a tertiary referral center in Taiwan | 作者: | YI-SHUAN SHEEN CHIA-YU CHU Wang S.-H. TSEN-FANG TSAI |
公開日期: | 2009 | 卷: | 20 | 期: | 6 | 起(迄)頁: | 340-343 | 來源出版物: | Journal of Dermatological Treatment | 摘要: | Background: Dapsone hypersensitivity syndrome (DHS) is a potentially life-threatening adverse drug reaction consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia. The incidence of DHS is estimated to be 2% in leprosy patients. Because the incidence of this drug eruption may be different in different ethnicities and diseases, we thought to investigate the incidence of DHS in non-leprosy patients. Methods: This is a retrospective study to examine the incidence, clinical manifestations and prognosis of DHS in non-leprosy patients who were given dapsone at the National Taiwan University Hospital between June 2001 and December 2005. Results: The incidence of DHS among non-leprosy patients was 1.66%. These patients ran a relatively benign course as compared with leprosy patients. Conclusion: The incidence of DHS among non-leprosy patients was compatible to that observed among leprosy patients. DHS in non-leprosy patients runs a favorable course with low morbidity in our study. ? 2008 Informa UK Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-72449164512&doi=10.3109%2f09546630802691317&partnerID=40&md5=6bd9301f677134abeb2626b47bdb5948 https://scholars.lib.ntu.edu.tw/handle/123456789/434712 |
ISSN: | 0954-6634 | DOI: | 10.3109/09546630802691317 | SDG/關鍵字: | corticosteroid; dapsone; adolescent; adult; aged; alkaline phosphatase blood level; article; child; clinical feature; controlled study; DRESS syndrome; drug withdrawal; female; foot edema; hepatosplenomegaly; human; human tissue; hypoalbuminemia; incidence; leprosy; leukocytosis; liver injury; lymphadenopathy; lymphocytosis; maculopapular rash; major clinical study; male; morbidity; papulovesicular rash; preschool child; priority journal; prognosis; school child; side effect; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Hemolytic; Child; Child, Preschool; Dapsone; Dermatitis, Exfoliative; Drug Hypersensitivity; Drug-Induced Liver Injury; Female; Fever; Hospitals, Teaching; Humans; Incidence; Inpatients; Leprostatic Agents; Lymphatic Diseases; Male; Middle Aged; Retrospective Studies; Skin Diseases; Syndrome; Taiwan |
顯示於: | 醫學系 |
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