https://scholars.lib.ntu.edu.tw/handle/123456789/434831
標題: | Increased expression of the natural killer cell inhibitory receptor CD94/NKG2A and CD158b on circulating and lesional T cells in patients with chronic plaque psoriasis | 作者: | YI-HUA LIAO SHIOU-HWA JEE BOR-CHING SHEU Huang Y.L. Tseng M.P. Hsu S.M. TSEN-FANG TSAI |
公開日期: | 2006 | 卷: | 155 | 期: | 2 | 起(迄)頁: | 318-324 | 來源出版物: | British Journal of Dermatology | 摘要: | Background: Psoriasis is a common inflammatory cutaneous disorder characterized by activated T-cell infiltration. T lymphocytes bearing natural killer cell receptors (NKRs) have been suggested to play an important role in the pathogenesis of psoriasis. However, the expression pattern of activating and inhibitory NKRs on T lymphocytes from psoriatic patients and its significance in psoriasis needs further study. Objectives: To investigate the pathogenesis of NKR-expressing T cells in psoriasis. Materials and methods Thirty patients with chronic plaque psoriasis and 20 healthy controls were enrolled in this study. The immunophenotypic profiles of NKRs, including CD56, CD16 (activating NKRs), CD158a, CD158b, CD94 and NKG2A (inhibitory NKRs), were analysed in peripheral blood T lymphocytes, as well as psoriatic lesional infiltrating T cells, by triple-fluorescence flow cytometry. Results: A significant increase of inhibitory CD8+ CD158b+, CD4- CD8- CD158b+ and CD8+ CD94/NKG2A+ T cells was found in the peripheral blood of patients with psoriasis when compared with controls. Tissue-infiltrating T lymphocytes expressing inhibitory receptors CD158b, CD94 and NKG2A were found in psoriatic lesions. There was a significant positive correlation between the increased percentage of circulating CD8+ CD94/NKG2A+ T cells and the Psoriasis Area and Severity Index. Conclusions: In the present study, we demonstrated increased proportions of particular subsets of inhibitory CD158b+ and/or CD94/NKG2A + T cells in patients with psoriasis. The elevation of these inhibitory NKR-expressing T cells was correlated with disease severity, which may signify the possibility of chronic antigen-driven stimulation and dysregulated cytokine production in the pathogenesis of psoriasis. ? 2006 British Association of Dermatologists. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745912540&doi=10.1111%2fj.1365-2133.2006.07301.x&partnerID=40&md5=8b3bd5c821ae38be3b8cf5253143c92a https://scholars.lib.ntu.edu.tw/handle/123456789/434831 |
ISSN: | 0007-0963 | DOI: | 10.1111/j.1365-2133.2006.07301.x | SDG/關鍵字: | CD16 antigen; CD56 antigen; CD94 antigen; natural killer cell receptor; natural killer cell receptor NKG2A; adolescent; adult; aged; article; blood analysis; blood sampling; cell infiltration; clinical article; controlled study; correlation analysis; disease severity; female; flow cytometry; fluorescence; human; immunophenotyping; male; natural killer cell; priority journal; psoriasis vulgaris; statistical significance; T lymphocyte; T lymphocyte subpopulation; Adolescent; Adult; Aged; Antigens, CD94; Female; Flow Cytometry; Humans; Killer Cells, Natural; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily D; Psoriasis; Receptors, Immunologic; Receptors, KIR; Receptors, KIR2DL1; Receptors, KIR2DL3; Severity of Illness Index; Skin; T-Lymphocyte Subsets |
顯示於: | 醫學系 |
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