Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: A retrospective cohort study from Taiwan
Journal
Journal of the American Academy of Dermatology
Journal Volume
68
Journal Issue
3
Pages
459
Date Issued
2013-03
Author(s)
Abstract
Background: The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown. Objective: We sought to investigate the incidence of sequelae, including less well-known sequelae, and long-term prognosis in patients with DRESS/drug-induced hypersensitivity syndrome. Methods: A retrospective cohort study was conducted at a medical center in northern Taiwan using a DRESS/drug-induced hypersensitivity syndrome database. Patients who were followed up for at least 1 year were included in the study. Results: Nine patients died before interview, whereas 43 patients completed a specially designed questionnaire. The overall cumulative incidence of long-term sequelae was 11.5% (6 of 52 patients). Four patients developed autoimmune diseases, specifically Graves disease (n = 2), type 1 diabetes mellitus (n = 1), and autoimmune hemolytic anemia (n = 1). Alopecia areata was also noted in 1 of the 2 patients with Graves disease. The other 2 patients developed renal failure after visceral involvement and required lifetime hemodialysis. Limitations: Our study included a small number of patients. Further, viral studies were not performed. Conclusion: The sequelae of DRESS can be divided into 2 major types that appear to occur in different age groups: young patients tend to develop autoimmune diseases, whereas elderly patients are more vulnerable to end-organ failure. ? 2011 by the American Academy of Dermatology, Inc.
Subjects
autoimmune diseases
drug reaction with eosinophilia and systemic symptoms
drug-induced hypersensitivity syndrome
sequelae
SDGs
Other Subjects
adult; aged; alopecia areata; article; autoimmune hemolytic anemia; clinical article; DRESS syndrome; female; follow up; Graves disease; hemodialysis; human; incidence; insulin dependent diabetes mellitus; kidney failure; male; medical record review; priority journal; prognosis; Taiwan; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Cohort Studies; Diabetes Mellitus, Type 1; Drug Hypersensitivity; Drug Toxicity; Eosinophilia; Female; Graves Disease; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Taiwan
Type
journal article