https://scholars.lib.ntu.edu.tw/handle/123456789/435674
標題: | A combination of Lactobacillus Mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice | 作者: | Chen Y.-T. Yang N.-S. Lin Y.-C. Ho S.-T. Li K.-Y. Lin J.-S. Liu J.-R. MING-JU CHEN JE-RUEI LIU |
公開日期: | 2018 | 卷: | 8 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | The difficulty of long-term management has produced a high rate of failure for obesity patients. Therefore, improving the efficacy of current obesity treatment is a significant goal. We hypothesized that combining a probiotic Lactobacillus Mali APS1 intervention with dieting could improve the efficacy of obesity and hepatic steatosis treatment compared to dieting alone. Mice were fed a high-fat diet for 6 weeks and then treated with: saline + normal diet and APS1 + normal diet (NDAPS1) for 3 weeks. NDAPS1 accelerated body weight loss and reduced caloric intake and fat accumulation. The fecal microbiome showed that accelerating weight loss by NDAPS1 resulted in restoring intestinal microbiota toward a pre-obese state, with alteration of specific changes in the obesity-associated bacteria. APS1 manipulated the gut microbiome's obesity-associated metabolites, followed by regulation of lipid metabolism, enhancement of energy expenditure and inhibition of appetite. The specific hepatic metabolites induced by the APS1-manipulated gut microbiome also contributed to the amelioration of hepatic steatosis. Our results highlighted a possible microbiome and metabolome that contributed to accelerating weight loss following treatment with a combination of APS1 and dieting and suggested that probiotics could serve as a potential therapy for modulating physiological function and downstream of the microbiota. ? 2018 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/435674 | ISSN: | 20452322 | DOI: | 10.1038/s41598-018-23844-y | SDG/關鍵字: | hormone; probiotic agent; adipose tissue; animal; body weight loss; caloric intake; diet; disease model; intestine flora; Lactobacillus; liquid chromatography; mass spectrometry; metabolism; metabolomics; mouse; obesity; pathology; procedures; Adipose Tissue; Animals; Chromatography, Liquid; Diet; Disease Models, Animal; Energy Intake; Gastrointestinal Microbiome; Hormones; Lactobacillus; Mass Spectrometry; Metabolomics; Mice; Obesity; Probiotics; Weight Loss |
顯示於: | 動物科學技術學系 |
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